A model of the factors affecting interstitial volume in oedema. Part II: Their effects at various abnormal steady-states.
Identifieur interne : 012F73 ( Main/Exploration ); précédent : 012F72; suivant : 012F74A model of the factors affecting interstitial volume in oedema. Part II: Their effects at various abnormal steady-states.
Auteurs : J R Casley-Smith [Australie]Source :
- Biorheology [ 0006-355X ]
Descripteurs français
- KwdFr :
- Espace extracellulaire (métabolisme), Espace extracellulaire (physiologie), Fibrose, Humains, Hydrolyse, Lymphoedème (métabolisme), Lymphoedème (physiopathologie), Maladies vasculaires (physiopathologie), Mathématiques, Modèles biologiques, Modèles théoriques, Oedème (métabolisme), Oedème (physiopathologie), Plaies et blessures (physiopathologie), Protéines (métabolisme).
- MESH :
- métabolisme : Espace extracellulaire, Lymphoedème, Oedème, Protéines.
- physiologie : Espace extracellulaire.
- physiopathologie : Lymphoedème, Maladies vasculaires, Oedème, Plaies et blessures.
- Fibrose, Humains, Hydrolyse, Mathématiques, Modèles biologiques, Modèles théoriques.
English descriptors
- KwdEn :
- Edema (metabolism), Edema (physiopathology), Extracellular Space (metabolism), Extracellular Space (physiology), Fibrosis, Humans, Hydrolysis, Lymphedema (metabolism), Lymphedema (physiopathology), Mathematics, Models, Biological, Models, Theoretical, Proteins (metabolism), Vascular Diseases (physiopathology), Wounds and Injuries (physiopathology).
- MESH :
- chemical , metabolism : Proteins.
- metabolism : Edema, Extracellular Space, Lymphedema.
- physiology : Extracellular Space.
- physiopathology : Edema, Lymphedema, Vascular Diseases, Wounds and Injuries.
- Fibrosis, Humans, Hydrolysis, Mathematics, Models, Biological, Models, Theoretical.
Abstract
A mathematical model has been used to investigate the alterations, in amount and importance, of the Factors controlling interstitial fluid volume in a number of steady-state oedemas. Steady-states were used because it is much easier to evaluate the effect of a specific Factor on oedema if all the others are constant. They are best compared if expressed in the same units: ml/min/100 g of tissue. The effects of lymphatic drainage on trauma are very important, as is the effect of tissue proteolysis on lymphoedema. Tissue proteolysis has minimal effects on the normal state and trauma; yet modelling its increase with benzo-pyrones markedly reduces oedema in both trauma and lymphoedema. Excess fibrosis greatly reduces lymphoedema. The effects of the individual Factors vary considerably between the different steady-states.
PubMed: 8374104
Affiliations:
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Part II: Their effects at various abnormal steady-states.</title><author><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name><affiliation wicri:level="1"><nlm:affiliation>Henry Thomas Laboratory, University of Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Henry Thomas Laboratory, University of Adelaide</wicri:regionArea><wicri:noRegion>University of Adelaide</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biorheology</title><idno type="ISSN">0006-355X</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Edema (metabolism)</term><term>Edema (physiopathology)</term><term>Extracellular Space (metabolism)</term><term>Extracellular Space (physiology)</term><term>Fibrosis</term><term>Humans</term><term>Hydrolysis</term><term>Lymphedema (metabolism)</term><term>Lymphedema (physiopathology)</term><term>Mathematics</term><term>Models, Biological</term><term>Models, Theoretical</term><term>Proteins (metabolism)</term><term>Vascular Diseases (physiopathology)</term><term>Wounds and Injuries (physiopathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Espace extracellulaire (métabolisme)</term><term>Espace extracellulaire (physiologie)</term><term>Fibrose</term><term>Humains</term><term>Hydrolyse</term><term>Lymphoedème (métabolisme)</term><term>Lymphoedème (physiopathologie)</term><term>Maladies vasculaires (physiopathologie)</term><term>Mathématiques</term><term>Modèles biologiques</term><term>Modèles théoriques</term><term>Oedème (métabolisme)</term><term>Oedème (physiopathologie)</term><term>Plaies et blessures (physiopathologie)</term><term>Protéines (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Edema</term><term>Extracellular Space</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Espace extracellulaire</term><term>Lymphoedème</term><term>Oedème</term><term>Protéines</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Espace extracellulaire</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Extracellular Space</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Lymphoedème</term><term>Maladies vasculaires</term><term>Oedème</term><term>Plaies et blessures</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Edema</term><term>Lymphedema</term><term>Vascular Diseases</term><term>Wounds and Injuries</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Fibrosis</term><term>Humans</term><term>Hydrolysis</term><term>Mathematics</term><term>Models, Biological</term><term>Models, Theoretical</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Fibrose</term><term>Humains</term><term>Hydrolyse</term><term>Mathématiques</term><term>Modèles biologiques</term><term>Modèles théoriques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A mathematical model has been used to investigate the alterations, in amount and importance, of the Factors controlling interstitial fluid volume in a number of steady-state oedemas. Steady-states were used because it is much easier to evaluate the effect of a specific Factor on oedema if all the others are constant. They are best compared if expressed in the same units: ml/min/100 g of tissue. The effects of lymphatic drainage on trauma are very important, as is the effect of tissue proteolysis on lymphoedema. Tissue proteolysis has minimal effects on the normal state and trauma; yet modelling its increase with benzo-pyrones markedly reduces oedema in both trauma and lymphoedema. Excess fibrosis greatly reduces lymphoedema. The effects of the individual Factors vary considerably between the different steady-states.</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Casley Smith, J R" sort="Casley Smith, J R" uniqKey="Casley Smith J" first="J R" last="Casley-Smith">J R Casley-Smith</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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